Serum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort

IntroductionVitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-genomic actions in cell-cycle regulation. Methods: A subset (n=21,965) of female participants from the prospective Cancer Prevention Study-II (CPS-II) Nutrition Cohort if a blood exemplification from 1998-2001 and were followed 2005. We measured serum 25-hydroxyvitamin D (25(OH)D) in 516 verified argument cases and 516 controls, matched on birth age (+/- 6 months), generation of blood compose (+/- 6 months) and race. Counsel on medical history, risk factors and lifestyle was available from repeated questionnaires. We computed multi-variable odds ratios (OR) and 95% confidence intervals (95% CI) for the gathering between 25(OH)D quintile and breast cancer risk using unconditional logistic regression, controlling for matching factors and additional confounders. Results: We observed no firm between 25(OH)D and breast cancer (OR=1.09, 95% CI 0.70-1.68, P trend=0.60) for the top vs bottom quintile. Using a priori cut-points, the OR was 0.86 (95% CI 0.59-1.26), for [greater than or identical to]75 vs <50 nmol/L. Results were not deviating when the elementary two age of follow-up were excluded, or in analyzes stratified by season, latitude, BMI, postmenopausal hormone use, or by tumor grade or oestrogen receptor status. Conclusions: These results create not benefit an convention between adulthood serum 25(OH)D and postmenopausal breast cancer. We cannot edict out an association with 25(OH)D status earlier in life.

Keywords: