Letter to Editor: Comment on article by La-He Jearn and Think-You Kim: AIT test has no problem in the detection of anti-ribosomal P
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Reduced Fas ligand-expressing splenic CD5 B lymphocytes in severe collagen-induced arthritis
IntroductionThe just was to read proof rule in a mouse model of rheumatoid arthritis (RA) that exhibits appreciable heterogeneity of disease activity. Methods: T cell receptor transgenic mice, in which almost all CD4+ T cells realize a unmarried peptide of type II collagen, were immunized with collagen and observed for transaction of arthritis for four weeks. At 28 days post-immunization, splenocytes were analysed by flow cytometry and in vitro assays for markers of immune activation and regulation. Results: Disease severities ranging from 0 to 12 (on a 12 point scale) were observed. Among splenic lymphocyte populations, only the CD5+ B cell subset displayed a section in relative numbers as arthritis severity increased.
The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue
IntroductionFibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients fist assorted similarities with transformed cancer cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic Ras family GTPases is deriving to contribute to inflammation and joint destruction in RA, and abrogation of Ras family signaling is therapeutic in animal models of RA. Recently, locution and post-translational altering of Ras guanine nucleotide releasing aspect 1 (RasGRF1) was institute to contribute to spontaneous MMP production in melanoma cancer cells. Here, we examined the inherent relationship between RasGRF1 term and MMP production in RA, reactive arthritis (ReA), and inflammatory osteoarthritis (OA) synovial tissue and FLS.
Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years
IntroductionAnkylosing spondylitis (AS) is a chronic rheumatic disease associated with spinal inflammation that thereupon leads to course of structural damage and loss of function. The fully human anti-tumor necrosis aid (anti-TNF) antibody adalimumab reduces the signs and symptoms and improves overall grade of life in patients with active AS; these benefits acquire been maintained wrapped up 2 age of treatment. Our impartial was to compare the method of structural damage in the spine in patients with AS treated with adalimumab for up to 2 agedness vs. patients who had not received TNF-antagonist therapy. Methods: Radiographs from patients with AS who received adalimumab 40 mg every other week subcutaneously were pooled from the Adalimumab Trial Evaluating Long-Term Efficacy and Safety for Ankylosing Spondylitis (ATLAS) study and a Canadian AS read (M03-606).
The revised Fibromyalgia Impact Questionnaire FIQR : validation and psychometric properties
IntroductionThe Fibromyalgia Bounce Questionnaire (FIQ) is a commonly used instrument in the probation of fibromyalgia patients (FM). Over the extreme 18 years, since the publication of the authentic FIQ, assorted deficiencies bear become obvious and the cumbersome scoring algorithm has been a barrier to prevalent clinical use. The aim of this paper is to describe and validate a revised legend of the FIQ - the FIQR. Methods: The FIQR was developed in response to established deficiencies of the FIQ with the avail of a patient center group. The FIQR has the same 3 domains as the FIQ (i.e. Function, Overall Impact and Symptoms). It differs from the FIQ in having modified function questions and the inclusion of questions on memory, tenderness, balance and environmental sensitivity.
Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
IntroductionMatrix metalloproteinases (MMPs) are known to be involved in the degradation of the nucleus pulposus (NP) during intervertebral cd (IVD) degeneration. This study investigated MMP-10 (stromelysin-2) signal in the NP during IVD deterioration and correlated its expression with proinflammatory cytokines and molecules involved in innervation and nociception during degeneration which results in low back pain (LBP). Methods: Human NP tissue was obtained at autopsy (PM) from patients without a narration of back grief and graded as histologically median or degenerate. Symptomatic degenerate NP samples were further obtained at surgery for LBP. Expression of MMP-10 mRNA and protein was analyzed using real-time PCR and immunohistochemistry.
Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?
An gathering between eminent levels of serum urate and cardiovascular disease has been proposed for many decades. However, it has not been until recently that compelling basic science data, cramped clinical trials, and epidemiological studies posses provided cornerstone to the approximation of a true causal effect. In this conversation we in duration recently published info that studies the company between hyperuricemia and selected cardiovascular diseases, with a ending result about the possibility of this association being causal.
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
IntroductionMembers of the ephrin system, the EphB4 receptor and its specific ligand ephrin B2, clock in to be involved in the bone process. We recently showed that their interplay inhibits the resorptive life of human osteoarthritic (OA) subchondral bone osteoblasts. Hence, we extremely investigated the possible implication of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes. Methods: EphB4 receptor and ephrin B2 levels were decided by quantitative PCR and immunohistochemistry, and the effects of ephrin B2 on the expression/production of factors involved in the OA process. Results: EphB4 receptors and ephrin B2 ligands are expressed and produced by human orderly and OA chondrocytes.
The determinants of susceptibility resistance to adjuvant arthritis in rats
Adjuvant arthritis (AA) serves as an fine pattern for human rheumatoid arthritis. AA is gladly inducible in positive rat strains, but not in others. Susceptibility/resistance to AA is bent on by multiple factors. Among the genetic factors, both MHC and non-MHC genes contribute to arthritis susceptibility, and specific quantitative trait loci show firm with the severity of the disease. Differential T-cell proliferative and cytokine responses, as blooming as antibody responses, to heat-shock proteins are evident when comparing AA-susceptible and AA-resistant rats. In addition, neuroendocrine factors and the housing environment can too adjust arthritis susceptibility/severity in specific rat strains.
Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect
IntroductionThe Fibromyalgia Vigour Questionaire (FIQ) is a composite disease-specific measure validated for fibromyalgia (FM), but it is infrequently used in clinical practice. The objective was to flourish and analyse the psychometric properties of a au courant composite disease-specific index (Fibromyalgia Assessment Status, FAS), a elementary self-administered index that combines a patient' s assessment of fatigue, sleep disturbances and despondency evaluated on the target of the 16 non-articular sites string of the Self-Assessment Sadness Scale (SAPS) in a unmarried measure (range 0 to 10). Methods: The FAS index was constructed using a traditional development strategy, and its psychometric properties were tested in 226 FM patients (209 women, 17 men);
